Investigation of AZT Sensitivity of HIV-1 Isolates from Patients Treated with AZT
نویسندگان
چکیده
منابع مشابه
AZT myopathy and HIV-1 polymyositis: one disease or two?
PURPOSE This paper discusses the association between inflammatory and mitochondrial pathologies in patients with HIV-1/AIDS treated with zidovudine (AZT). METHODS We present the clinical and pathological details of a 52-year-old HIV-1 positive male who presented with progressive muscle weakness. We also review the current literature and address the debated pathogenesis of the inflammatory pat...
متن کاملAZT: Unsafe at Any Dose?
html. file:///Users/dad/Documents/Green/AIDS/ARAS/aras.ab.ca ƒ/test/azt-integrated.html (2 of 45)3/27/2006 6:16:14 PM AZT: Unsafe at Any Dose? “1 patient [out of a grand total of 10 in this clinical trial] suffered from severe anemia resulting from ZDV [AZT] therapy” Lafeuillade A et al. Pilot study of a combination of highly active antiretroviral therapy and cytokines to induce HIV-1 remission...
متن کاملWhy Do HIV-1 and HIV-2 Use Different Pathways to Develop AZT Resistance?
The human immunodeficiency virus type 1 (HIV-1) develops resistance to all available drugs, including the nucleoside analog reverse transcriptase inhibitors (NRTIs) such as AZT. ATP-mediated excision underlies the most common form of HIV-1 resistance to AZT. However, clinical data suggest that when HIV-2 is challenged with AZT, it usually accumulates resistance mutations that cause AZT resistan...
متن کاملK65R in Subtype C HIV-1 Isolates from Patients Failing on a First-Line Regimen Including d4T or AZT: Comparison of Sanger and UDP Sequencing Data
BACKGROUND We and others have shown that subtype C HIV-1 isolates from patients failing on a regimen containing stavudine (d4T) or zidovudine (AZT) exhibit thymidine-associated mutations (TAMs) and K65R which can impair the efficacy of Tenofovir (TDF) at second line. Depending on the various studies, the prevalence of K65R substitution as determined by the Sanger method ranges from 4 to 30%. Ou...
متن کاملA computational model of mitochondrial AZT metabolism.
The mechanisms of the mitochondrial toxicity of AZT (azidothymidine; zidovudine) are not clear. The two main contenders are the incorporation of phosphorylated AZT into the mtDNA (mitochondrial DNA) and the competitive inhibition of natural deoxynucleotide metabolism. We have built a computational model of AZT metabolism in mitochondria in order to better understand these toxicity mechanisms. T...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the Japanese Association for Infectious Diseases
سال: 1993
ISSN: 1884-569X,0387-5911
DOI: 10.11150/kansenshogakuzasshi1970.67.311